Diethylene glycol (DEG) is employed as a comonomer during the synthesis of poly (ethylene terephthalate) (PET). It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. These measures quickly ended the advance of the epidemic. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. Food Chem., 50, 2002, 7616-7621. ass: Standard polar; Column diameter: 0.32 mm; Column length: 50 m; Column type: Capillary; Heat rate: 2 K/min; Start T: 50 C; End T: 200 C; End time: 40 min; Start time: 5 min; CAS no: 111466; Active phase: Carbowax 20M; Carrier gas: He; Data type: Linear RI; Authors: Chen, C.-C.; Kuo, M.-C.; Liu, S.-E.; Wu, C.-M., Volatile components of salted and pickled prunes (Prunus mume Sieb. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. III. In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. It is also incompatible with strong bases. Other resolutions: 320 × 56 pixels | 640 × 111 pixels | 800 × 139 pixels | 1,024 × 178 pixels | 1,280 × 223 pixels. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. , Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. Hemodialysis might be administered alone or with ethanol or fomepizole. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.The structure of PEG is commonly expressed as H−(O−CH 2 −CH 2) n −OH. As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. , When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. Diethylene glycol has been detected in drinking water, ground water, surface water, and indoor air resulting from its release to the environment from its production and use. They have closely related structures; a diethylene glycol is a combination of to ethylene glycol molecules. Industry Circular No. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. , "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. Ethylene Glycols & Monofunctional Ethylene Glycols [Chemical Structural Class] Monofunctional Ethylene Glycols [Chemical Structural Class] Chemistry. File:Diethylene glycol structure.svg. The resulting product is two ethylene glycol molecules joined by an ether bond. et Zucc. The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. Di-ethyleenglycol wordt bereid door etheenoxide met een overmaat water te reageren. Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. It derives from a diethylene glycol. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. Food Chem., 34(1), 1986, 140-144. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. 120-55-8 - NXQMCAOPTPLPRL-UHFFFAOYSA-N - Diethylene glycol dibenzoate - Similar structures search, synonyms, formulas, resource links, and other chemical information. Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH 2 OH) 2. They identified Tianhong Fine Chemicals Factory as the manufacturer. Footnote 8. Most ethylene glycol antifreeze contains a few percent diethylene glycol, present as an byproduct of ethylene glycol production. (Mono-)ethyleenglycol kan ook omgezet worden tot di-ethyleenglycol door het te laten reageren met etheenoxide. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. Beilstein/REAXYS Number 1739225 . VII. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Depending on the conditions, varying amounts of DEG and related glycols are produced. Dimethoxyethane, also known as glyme, monoglyme, dimethyl glycol, ethylene glycol dimethyl ether, dimethyl cellosolve, and DME, is a colorless, aprotic, and liquid ether that is used as a solvent, especially in batteries. , In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. 111-46-6. diethylene synonyms, diethylene pronunciation, diethylene translation, English dictionary definition of diethylene. Diethylene glycol dihexanoate contains total 50 bond(s); 20 non-H bond(s), 2 multiple bond(s), 16 rotatable bond(s), 2 double bond(s), 2 ester(s) (aliphatic) and 1 ether(s) (aliphatic). Furthermore, it is listed in section II, perfume and aromatic raw materials. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. Ethylene glycol and diethylene glycol are organic compounds that have applications in the production of coolants for engines. They react with oxoacids and carboxylic acids to form esters plus water. In July 2007 the Spanish authorities informed the Commission services about their findings ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite, Compounds with the same molecular formula, Search Google for structures with same skeleton, WARNING: Causes CNS effects, skin, eye, & lung irritation, WARNING: Irritates skin and eyes, harmful if swallowed. , Based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular filtration. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. Jump to navigation Jump to search. Ser., , 1973, 51-63. ass: Standard non-polar; Column diameter: 0.20 mm; Column length: 25 m; Column type: Capillary; Heat rate: 6 K/min; Start T: 50 C; End T: 250 C; CAS no: 111466; Active phase: OV-101; Carrier gas: N2/He; Phase thickness: 0.10 um; Data type: Normal alkane RI; Authors: Zenkevich, I.G., Experimentally measured retention indices., 2005. ass: Standard non-polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 260 C; Start time: 5 min; CAS no: 111466; Active phase: DB-1; Carrier gas: He; Phase thickness: 3 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 230 C; Start time: 7 min; CAS no: 111466; Active phase: DB-Wax; Carrier gas: He; Phase thickness: 1 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 200 C; End time: 10 min; Start time: 1 min; CAS no: 111466; Active phase: HP-Wax; Data type: Normal alkane RI; Authors: Gallet, G.; Erlandsson, B.; Albertsson, A.-C.; Karlsson, S., Thermal oxidation of poly(ethylene oxide-propylene oxide-ethylene oxide) triblock copolymer: focus on low molecular weight degradation products, Polym. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. ; Pietroluongo, M.; de Maria, C.A.B., Flavor composition of cashew (Anacardium occidentale) and marmeleiro (Croton species) honeys, J. Agric. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities..  The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. , At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Some time later, Wang found a reference to diethylene glycol in a chemical book.  DEG is a widely used solvent. … DEG is a widely used solvent.  This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. Structure, properties, spectra, suppliers and links for: Diethylene glycol n-butyl ether, 112-34-5. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. ETHER, ACETONE, ALCOHOL, ETHYLENE GLYCOL: Synonyms: DEG DIGLYCOL 2,2'-OXYDIETHANOL 3-OXAPENTANE-1,5-DIOL BIS(2-HYDROXYETHYL)ETHER DI(2-HYDROXYETHYL) ETHER: Technique: NEAT: Use: LUBRICANT AND SOLVENT . Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. CopyCopied, CSID:13835180, http://www.chemspider.com/Chemical-Structure.13835180.html (accessed 19:38, Dec 31, 2020)
 It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. Define diethylene. The Henry's Law constant for diethylene glycol bis (methacrylate) is estimated as 7.9X10-10 atm-cu m/mole (SRC) using a fragment constant estimation method (1). , InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, InChI=1/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, Except where otherwise noted, data are given for materials in their, 1937 – The Massengill Incident (United States). The children later developed kidney failure and died. Sigma-Aldrich offers a number of Diethylene glycol products.