Diethylene glycol (DEG) is employed as a comonomer during the synthesis of poly (ethylene terephthalate) (PET). It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. These measures quickly ended the advance of the epidemic. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. Food Chem., 50, 2002, 7616-7621. ass: Standard polar; Column diameter: 0.32 mm; Column length: 50 m; Column type: Capillary; Heat rate: 2 K/min; Start T: 50 C; End T: 200 C; End time: 40 min; Start time: 5 min; CAS no: 111466; Active phase: Carbowax 20M; Carrier gas: He; Data type: Linear RI; Authors: Chen, C.-C.; Kuo, M.-C.; Liu, S.-E.; Wu, C.-M., Volatile components of salted and pickled prunes (Prunus mume Sieb. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. III. In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. It is also incompatible with strong bases. Other resolutions: 320 × 56 pixels | 640 × 111 pixels | 800 × 139 pixels | 1,024 × 178 pixels | 1,280 × 223 pixels. The CDC employed modern laboratory equipment to analyze the samples and confirm the results: the samples contained approximately 8% v/v DEG. Bogdanich, W. "Toxic Toothpaste Made in China Is Found in U.S. ". For late diagnosis where ethanol or fomepizole is ineffective, because DEG has already been metabolized, hemodialysis becomes the only treatment available. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. Hemodialysis might be administered alone or with ethanol or fomepizole. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.The structure of PEG is commonly expressed as H−(O−CH 2 −CH 2) n −OH. As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. [29], When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. Diethylene glycol has been detected in drinking water, ground water, surface water, and indoor air resulting from its release to the environment from its production and use. They have closely related structures; a diethylene glycol is a combination of to ethylene glycol molecules. Industry Circular No. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. Ethylene Glycols & Monofunctional Ethylene Glycols [Chemical Structural Class] Monofunctional Ethylene Glycols [Chemical Structural Class] Chemistry. File:Diethylene glycol structure.svg. The resulting product is two ethylene glycol molecules joined by an ether bond. et Zucc. The factory of the medication manufacturer, Pharval, was subsequently investigated by Dr. Joel Selanikio (also of CDC, and an Epidemic Intelligence Service classmate of Katherine O'Brien). Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. Di-ethyleenglycol wordt bereid door etheenoxide met een overmaat water te reageren. Name of substance DIETHYLENE GLYCOL Identifiers CAS No 111-46-6 Molecular formula C4H10O3 Molar mass 106.1 g/mol SECTION 4: First-aid measures 4.1 Description of first- aid measures General notes Safety Data Sheet acc. It derives from a diethylene glycol. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. Food Chem., 34(1), 1986, 140-144. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. 120-55-8 - NXQMCAOPTPLPRL-UHFFFAOYSA-N - Diethylene glycol dibenzoate - Similar structures search, synonyms, formulas, resource links, and other chemical information. Ethylene glycol (IUPAC name: ethane-1,2-diol) is an organic compound with the formula (CH 2 OH) 2. They identified Tianhong Fine Chemicals Factory as the manufacturer. Footnote 8. Most ethylene glycol antifreeze contains a few percent diethylene glycol, present as an byproduct of ethylene glycol production. (Mono-)ethyleenglycol kan ook omgezet worden tot di-ethyleenglycol door het te laten reageren met etheenoxide. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. Diethylene glycol is used in the manufacture of saturated and unsaturated polyester resins, polyurethanes, and plasticizers. Beilstein/REAXYS Number 1739225 . VII. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Depending on the conditions, varying amounts of DEG and related glycols are produced. Dimethoxyethane, also known as glyme, monoglyme, dimethyl glycol, ethylene glycol dimethyl ether, dimethyl cellosolve, and DME, is a colorless, aprotic, and liquid ether that is used as a solvent, especially in batteries. [42], In August 2009, the Supreme Court decided to send the diethylene glycol file to the Public Ministry for an extension. 111-46-6. diethylene synonyms, diethylene pronunciation, diethylene translation, English dictionary definition of diethylene. Diethylene glycol dihexanoate contains total 50 bond(s); 20 non-H bond(s), 2 multiple bond(s), 16 rotatable bond(s), 2 double bond(s), 2 ester(s) (aliphatic) and 1 ether(s) (aliphatic). Furthermore, it is listed in section II, perfume and aromatic raw materials. Siegfried Rebsdat and Dieter Mayer "Ethylene Glycol" in Ullmann’s Encyclopedia of Industrial Chemistry, 2002, Wiley-VCH, Weinheim. FDA Detains One Contaminated Shipment, Issues Import Alert", June 1, 2007. Ethylene glycol and diethylene glycol are organic compounds that have applications in the production of coolants for engines. They react with oxoacids and carboxylic acids to form esters plus water. In July 2007 the Spanish authorities informed the Commission services about their findings ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, WARNING: Causes CNS effects, skin, eye, & lung irritation, WARNING: Irritates skin and eyes, harmful if swallowed. [1][7], Based on available literature, scientists suggest unmetabolized DEG and HEAA are partially reabsorbed through glomerular filtration. What began as a local alert revealed a global problem in more than 30 countries and involving more than thirty brands. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. Jump to navigation Jump to search. Ser., , 1973, 51-63. ass: Standard non-polar; Column diameter: 0.20 mm; Column length: 25 m; Column type: Capillary; Heat rate: 6 K/min; Start T: 50 C; End T: 250 C; CAS no: 111466; Active phase: OV-101; Carrier gas: N2/He; Phase thickness: 0.10 um; Data type: Normal alkane RI; Authors: Zenkevich, I.G., Experimentally measured retention indices., 2005. ass: Standard non-polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 260 C; Start time: 5 min; CAS no: 111466; Active phase: DB-1; Carrier gas: He; Phase thickness: 3 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.53 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 230 C; Start time: 7 min; CAS no: 111466; Active phase: DB-Wax; Carrier gas: He; Phase thickness: 1 um; Data type: Normal alkane RI; Authors: J&W Scientific, Solvent Retention Data, 2003. ass: Standard polar; Column diameter: 0.25 mm; Column length: 30 m; Column type: Capillary; Heat rate: 10 K/min; Start T: 40 C; End T: 200 C; End time: 10 min; Start time: 1 min; CAS no: 111466; Active phase: HP-Wax; Data type: Normal alkane RI; Authors: Gallet, G.; Erlandsson, B.; Albertsson, A.-C.; Karlsson, S., Thermal oxidation of poly(ethylene oxide-propylene oxide-ethylene oxide) triblock copolymer: focus on low molecular weight degradation products, Polym. It can also serve as a dispersant in organosols and can also be used in preparation of plasticizers. 111-46-6 - MTHSVFCYNBDYFN-UHFFFAOYSA-N - Diethylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. ; Pietroluongo, M.; de Maria, C.A.B., Flavor composition of cashew (Anacardium occidentale) and marmeleiro (Croton species) honeys, J. Agric. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[38]. [29] The United States Food and Drug Administration also issued an Industry Guidance Document “intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)” and recommended appropriate testing procedures for the use of glycerin. [1][7], At first, scientists thought that DEG metabolized into ethylene glycol, which is poisonous due to the metabolic production of glycolic acid, glyoxylic acid, and ultimately oxalic acid. About half were receiving Lisinopril (a blood pressure medicine), and many did not remember clearly if they had been taking other drugs. Some time later, Wang found a reference to diethylene glycol in a chemical book. [1] DEG is a widely used solvent. … DEG is a widely used solvent. [19] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. Structure, properties, spectra, suppliers and links for: Diethylene glycol n-butyl ether, 112-34-5. Massengill Co. (a Tennessee drug company), manufactured sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. ETHER, ACETONE, ALCOHOL, ETHYLENE GLYCOL: Synonyms: DEG DIGLYCOL 2,2'-OXYDIETHANOL 3-OXAPENTANE-1,5-DIOL BIS(2-HYDROXYETHYL)ETHER DI(2-HYDROXYETHYL) ETHER: Technique: NEAT: Use: LUBRICANT AND SOLVENT . Meanwhile, in Panama, De la Cruz, legal representative of Medicom, remains in jail pending a trial. CopyCopied, CSID:13835180, http://www.chemspider.com/Chemical-Structure.13835180.html (accessed 19:38, Dec 31, 2020) [2] It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. Define diethylene. The Henry's Law constant for diethylene glycol bis (methacrylate) is estimated as 7.9X10-10 atm-cu m/mole (SRC) using a fragment constant estimation method (1). [71][72], InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, InChI=1/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2, Except where otherwise noted, data are given for materials in their, 1937 – The Massengill Incident (United States). The children later developed kidney failure and died. Sigma-Aldrich offers a number of Diethylene glycol products. Diethylene glycol is one of several glycols derived from ethylene oxide. [1], DEG is produced by the partial hydrolysis of ethylene oxide. Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. Akad. Multi-responsive (diethylene glycol) methyl ether methacrylate–methacrylic acid (DEGMA–MAA) copolymers were synthesised for the first time via RAFT polymerisation, and the structure–activity interplay of statistical and block copolymers in solution was compared. [1] In personal care products (e.g. [70], In the first week of 2020, around 17 children from Ramnagar, in the union territory of Jammu and Kashmir, were hospitalised, more than half of whom died of kidney failure. Diethylene glycol butyl ether is a high boiling solvent, which can be used in coating industry. Schuler, R. L. et al (1984) Results of testing fifteen glycol ethers in a short-term in vivo reproductive toxicity assay. Wang Guiping discovered how easy it was to enter China’s pharmaceutical supply business and earn extra money. Panamanian officials traced the toothpaste to a local company in the Colón Free Trade Zone. The Henry's Law constant for diethylene glycol dibenzoate is estimated as 3X10-12 atm-cu m/mole (SRC) using a fragment constant estimation method (1). 111-90-0 - XXJWXESWEXIICW-UHFFFAOYSA-N - Diethylene glycol monoethyl ether [NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. [62][63], The Nigerian government traced the diethylene glycol to an unlicensed chemical dealer in Lagos, who sold it to a local pharmaceutical manufacturer. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. It has a molecular weight of around 30 000 and its polyethylene oxide segments have an average molecular weight of about 1000. The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. Royal Society of Chemistry. The primary results revealed that the mixture was more effective than using salt alone. Molecular Weight. When 105 people died in 15 states during the months of September and October, the trail led back to the elixir, and the toxic potential of this chemical was revealed. Return to footnote 7 referrer. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. 111-77-3 - SBASXUCJHJRPEV-UHFFFAOYSA-N - Diethylene glycol monomethyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. Fourteen patients received hemodialysis, but the treatment failed. The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. Once verifying that he was fine, he shipped it to Qiquihar No. "Austrian power plant to burn 'bad' wine. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the. Video shows what diethylene glycol means. [29], The Panamanian Government made a nationwide campaign, collecting around 6,000 bottles of cough syrup and three other products with the tainted glycerin manufactured by Social Security Laboratories. Beilstein/REAXYS Number 1736441 . Dermal absorption is very low, unless it is administered on broken or damaged skin. U.S. Food and Drug Administration Press Release. All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. Its toxicity has been assessed. PubChem Substance ID 24881024. It is mainly used for two purposes, as a raw material in the manufacture of polyester fibers and for antifreeze formulations. The symptoms seemed to match with Guillain–Barré syndrome, but these patients were also losing their ability to urinate, a symptom not related to Guillain–Barré. Structure, properties, spectra, suppliers and links for: Diethylene glycol monobenzoate, 20587-61-5. Under normal conditions, diethylene glycol has no detectable odor; however, under high vapor concentrations, a slightly sweet odor may be detected. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Anal. It is an odorless, colorless, sweet-tasting, viscous liquid. The outbreak forced the government to ban the sale of paracetamol elixirs in December 1992, causing a decline of 53% in the admission of patients with kidney failure and an 84% decline in admissions by unexplained kidney failure. Bureau of Alcohol, Tobacco, and Firearms. Doctors had no idea what was happening: the mysterious illness was attacking elderly citizens with hypertension and diabetes history. EC Number 203-961-6. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. Later on, HEAA leaves the liver through the bloodstream, being partially filtered in the kidneys for elimination. The episode resulted in the deaths of 21 patients and the discovery of glycerin contaminated with 18.5% v/v of DEG. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. NACRES NA.22 Articles of Diethylene glycol are included as well. Vestis Kim. Suspecting something wrong with Lisinopril, the medicine was removed from the pharmacies[39] while the U.S. Food and Drug Administration conducted lab analyses, revealing the blood pressure drug was safe; CDC epidemiologists were then invited to participate. [3], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. [55][56] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. Mass Spectral Interpretation A. Glycols and Glycol Ethers (Underivatized) In the mass spectra of di- and tri-ethylene glycol, the largest peak observed is at m/z 45. [38], Ending June 1996, the FDA had discovered counterfeit glycerin traced back to Chemical Trading and Consulting (a German broker), which bought 72 barrels of the syrup from Vos B.V., a Dutch company. A dilute solution of diethylene glycol can also be used as a cryoprotectant; however, ethylene glycol is much more commonly used. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH 2 CH 2 OCH 2 CH 2 OH Molecular Weight: 134.17 [26] The next year, an Austrian electric power plant (Österreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. Soon, patients from other parts of the country started to arrive at hospitals. Diethylene glycol poisoning can also result in hepatic disease, pancreatitis, and neurologic abnormalities, which appear up to a few days after exposure [8,12]. [6] It is also a component in brake fluid, lubricants, wallpaper strippers, artificial fog and haze solutions, and heating/cooking fuel. [20], In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. The company tested the new product, Elixir Sulfanilamide, for viscosity, appearance and fragrance. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[1] and others suggest this is the LD30. Seventeen other persons have also been charged related to this incident. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. [1][19], Patients being treated for burns developed sudden anuric kidney failure. Other resolutions: 320 × 56 pixels | 640 × 111 pixels | 800 × 139 pixels | 1,024 × 178 pixels | 1,280 × 223 pixels. Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements."[4]. [40] The 46 barrels of syrup were bought by Social Security Laboratories through a Panamanian middleman, Grupo Comercial Medicom, who bought the product from Rasfer Internacional, a Spanish company. [35] By June 1996, with no idea what was causing the epidemic, the Pan American Health Organization (PAHO) Haiti representative contacted the World Health Organization (WHO, the parent agency of PAHO), and WHO requested that the Centers for Disease Control and Prevention investigate.[36][29][37]. Czech. Between November 1995 and June 1996, almost 109 children admitted to the University Hospital in Port-au-Prince, Haiti, presented with acute kidney failure. Diethylene glycol diacetate is an acetate ester that is the diacetate obtained by the formal condensation of the two hydroxy groups of diethylene glycol with two molecules of acetic acid respectively. [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. Besides Wang, five employees of Qiquihar were prosecuted. ", "Letter from Bombay. Diethylene glycol is an organic compound having the chemical formula C 4 H 10 O 3. 1.1±0.1 g/cm3. [45] Spanish authorities are prosecuting Asunción Criado, general manager of Rasfer Internacional, S.A., and await Panamanian citizens, René Luciani (former Social Security Director) and Jéssica Rodríguez (former Purchase National Director) for their hearings. nanoparticle, <250 nm particle size (DLS), paste, 53-57 wt. This value indicates that diethylene glycol bis (methacrylate) will be essentially nonvolatile from water surfaces (2,SRC). After ingestion, DEG is absorbed through the gastrointestinal tract and distributed by the bloodstream throughout the body, reaching peak blood concentrations within 30 to 120 minutes. It is completely miscible with water and many organic liquids. [11] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Laboratory findings in clinical assessment of diethylene glycol can include an elevated osmolar gap, elevated anion gap, elevated creatinine, and acidosis [8,11,12]. An alternating copolymer of diethylene glycol terephthalate (hydrophobic) and polyethylene oxide (hydrophilic) has gained broad application in moisture management finishing. DEG is a widely used solvent. Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. Mr. Wang was caught and Qiquihar was shut down by the authorities. [47], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims [48], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. [49][50][51] For the end of the month, the Chinese government committed to investigate the “supposedly” tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. The toothpaste was labeled as “Manufactured in South Africa” and contained misspellings like "isclinically", "SOUTH AFRLCA" and "South African Dental Assoxiation". Degrad. Diethylene Glycol Monoethyl Ether ... Other Compounds by Structure Classification. Ethylene glycol-TMS, diethylene glycol-TMS, and glycerol-TMS 30 m DB-1 column or 30 m DB-5 column, 60–175° at 4°/min. All patients are likely to suffer significant morbidity. This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. It is completely miscible with water and many Structure: References: CAS number: 111466: 14: name: diethylene glycol: 14: synonyms % in diethylene glycol monobutyl ether/ethylene glycol, 99.9% trace metals basis Sigma-Aldrich pricing »Diethylene Glycol Stearates is a mixture of diethylene glycol monoesters and diesters of stearic and palmitic acids.It contains not less than 45.0percent of monoesters produced from the condensation of ethylene glycol and stearic acid of vegetable or animal origin. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. Incidents include its use in China as a component of cheap toothpaste, and by winemakers in Europe as an adulterant to create a "sweet" wine. Diethylene glycol. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. At room temperature, it is a colorless and odorless liquid. [3] In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. Structure, properties, spectra, suppliers and links for: Triethylene glycol, 112-27-6, 928-40-5. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. Molecular Weight 134.17 . Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. Data Source. It appears diethylene glycol is more hazardous to humans than implied by oral toxicity data in laboratory animals.[1]. [39], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. [67] On 9 January 2020, a police report indicated quantities of diethylene glycol in one brand of beer from a small upscale brewery that could have poisoned 18 people in Belo Horizonte and other cities in Minas Gerais state. [31], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. CAS Number. Rat models suggest DEG is metabolized in the liver by enzyme NAD-dependent alcohol dehydrogenase (ADH) into a hydrogen ion, NADH and 2-hydroxyethoxyacetaldehyde (C4H8O3). Structure of the coordination complex NbCl 3 (dimethoxyethane)(3-hexyne). 111-77-3 - SBASXUCJHJRPEV-UHFFFAOYSA-N - Diethylene glycol monomethyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. Vos records revealed the syrup had been bought from Sinochem International Chemicals Company through a German trader, Metall-Chemie. When released to soil or water, diethylene glycol is highly mobile; adsorption to soil and sediment is very low; volatilization is not expected to be important. When urine analyses for a series of metals, pesticides or their metabolites resulted negative, CDC scientists recalled the Nigeria and Haiti incidents. Synonym: 2-(2-Ethoxyethoxy)ethanol, CARBITOL ™, Diethylene glycol ethyl ether, Diethylene glycol monoethyl ether, Ethyldiglycol Linear Formula: C 2 H 5 OCH … Retention indices of amines in some polar and unpolar stationary phases, Latv. Polyethylene glycol (PEG; / ˌ p ɒ l i ˈ ɛ θ əl ˌ iː n ˈ ɡ l aɪ ˌ k ɒ l,-ˌ k ɔː l /) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.The structure of PEG is commonly expressed as H−(O−CH 2 −CH 2) n −OH. [3] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. CONTENTS. ), J. Agric. [52], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. It is a humectant for tobacco, cork, printing ink, and glue. Learn more about Diethylene glycol dihexanoate chemical structure at Mol-Instincts. Chem. PRODUCT PROFILE: Diethylene glycol: Major uses: Polyurethane (PU), 25% unsaturated polyester resins, 20% triethylene glycol (TEG) and tetraethylene glycol, 9% antifreeze blending, 8% solvents, 7% morpholine, 7% natural gas dehydration, 4% textiles, 3% 1,4-dioxane, 2% miscellaneous, 15% (2006).